Hi YC, Thanks for sharing the information. ADS131M02 can measure a differential input signal up to -1.2V~1.2V, and also it can operate up to 64ksps data rate, so there is no issue for you to use this ADC to measure your signal, but you may have to consider the following specifications: The higher data rate, the higher noise, for example, the noise will be 75.34uVrms on ADS131M02 when the data rate is 64ksps and Gain=1. The noise is much higher than your minimum signal 100uV on the ADC input. The offset error is 175uV typical on ADS131M02, the global-chop mode can be used to improve the offset and the noise but it will increase the settling time and limit the data rate of the ADC. A calibration can be considered as well. ADS131A02 is 2-ch simultaneous-sampling delta-sigma ADC that can support the data rate up to 128ksps, its noise is lower than ADS131M02 under the same conditions, 22.64uVrms at 64ksps data rate and Gain=1, an offset error calibration is needed. ADS131A02 supports a differential or single-ended input signal. I'm not sure whether a simultaneous-sampling ADC is definitely required in your design or not. TI has other precision ADC that has lower noise, but I would suggest you to take a look at ADS131A02 first. BR, Dale
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