Hello Grady, Although the ADS1261 does not have a gain setting of 250 we have significantly better noise performance at higher data rates. If you look at the noise table on page 24 in the ADS1261 datasheet and page 10 in the AD7730 datasheet you can see that our RMS noise and effective resolution is better. We do not have any devices currently released that can achieve a gain of 250. Regards, Josh
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