Hi Ramesh,
Thanks for the additional information. Something I didn't notice when giving my previous response is you have AVDD connected to REFIN+ and REFOUT. If you are using 5V as your reference, then you should not connect the REFOUT pin to the REFIN+. Having both references connected will cause an issue as the default register settings on power up is to turn on the internal reference. Even if your program turns off the reference, it will still be competing with the 5V supply until the register is reconfigured. This means you either need to disconnect the AVDD supply from REFIN+ or you need to disconnect the REFOUT from REFIN+. You should not have them both connected at the same time.
I'm confused by what you were trying to tell me about U6. Is the INA826 (U6) actually connected on your board? This is not properly connected on the schematic, and even if it were connected properly it can cause serious problems. The Absolute Maximim input to any of the analog inputs is AVDD+0.3V and AVSS-0.3V. U6 would potentially be in violation. Your other analog inputs may be in violation as well. As I do not know where the SIG signals originate, they must be referenced to AVSS where the inputs remain within the correct common mode of the MSC1210. Your inputs, both analog and digital, must be protected so as to not allow an out of Absolute Maximum condition.
Best regards,
Bob B