Should be OK. Check the formats available in the sample setup files on the product folder though to make sure that your required formats are supported since, whilst any format is programmable, there will be limited support available in configuring formats which are not already in the examples.
Filtering requirements depends on your quality requirements. Higher quality output can be generated by filtering, but for VGA resolutions this is difficult since every pixel frequency requires different cutoff frequencies. If you are limiting to SMPTE and not VESA then the problem space is smaller. If you are including all VESA resolutions then you either live with groups of resolutions in filter bands or create a complex, flexible filter.
BR,
Steve